Abstract Background: One of the main adverse reactions of adjuvant radiotherapy for breast cancer is radiodermatitis. Objective: To assess the incidence of radiodermatitis in women with breast cancer, identify factors associated with its severity and determine the time at which this event occurs. Methods: Prospective cohort study in 113 women with breast cancer who were evaluated before radiotherapy and at every fifth session until the end of treatment. Logistic regression and Cox proportional regression model were used for the assessment of risk factors; P values < 0.05 were considered significant. Results: The incidence rate of radiodermatitis was 98.2% and it was demonstrated that for each additional point of the Body Mass Index (BMI), the chance of occurrence of grades II to IV radiodermatitis increases by 14% (OR = 1.14 [95% CI 1.04–1.26]; p = 0.004) and statin use increases the risk of more severe skin lesions by four-fold (OR = 4.27 [95% CI 1.11–16.42]; p = 0.035). The exclusive use of hydrogel for skin hydration was an independent factor in delaying the onset of radiodermatitis (HR = 0.55 [95% CI 0.36–0.82]; p = 0.004). Study limitations: The main limitation of this study was its external validity. The identified factors should be considered for services and populations similar to those in this study. Conclusions: There was a high incidence of radiodermatitis and its severity was related to higher BMI, statin use; there was a protective effect of hydrogel use.

ABSTRACT Tomato is an important economic crop due to its consumption and production worldwide. However, like other crops, it is susceptible to pathogens, being necessary agrochemicals to prevent diseases and improve the production of fruits. Among the sustainable alternatives to crop production, microbial inoculants are used as biofungicide and biostimulants for plant development. Thus, this work aimed to evaluate the biocontrol potential of seven Trichoderma spp. isolates (T1, T2, T3, T4, T15, T17, and T19) against tomato pathogens in vitro experiments, and their potential to improve tomato growth. The Trichoderma spp. antagonism was investigated against Alternaria sp. 003/09, Botrytis sp. 006/13, Fusarium sp. 007/09, and Stemphylium sp. A73. Dual culture, volatile, and diffusible compounds activity tests showed that all new Trichoderma spp. tested could reduce the mycelial growth of all tested pathogens, highlighting T15 and T17 isolates. Seed and soil inoculation revealed very contrasting results: Trichoderma sp. T17 showed a beneficial effect when inoculated in soil, reducing the percentage of yellowish leaves, and increasing dry weight and stem diameter. Inoculation of Trichoderma sp. T17 in the seed increases hypocotyl and radicle lengths, and the seed vigor index. Finally, the strains studied present the potential to be used to develop biocontrol products.

Resumo: Introdução: O novo coronavírus (severe acute respiratory syndrome coronavirus - SARS-CoV-2) disseminou-se rapidamente em todo o mundo causando a Coronavirus Disease 2019 - COVID-19, uma doença respiratória potencialmente grave, que se configura como uma ameaça à vida de milhares de pessoas, sobretudo profissionais de saúde que frente à exposição ocupacional aumentam suas vulnerabilidades e integrando as estatísticas de casos, óbitos e letalidade. Objetivo: descrever a situação epidemiológica dos profissionais de enfermagem no Brasil acometidos pela COVID-19. Método: Estudo epidemiológico, observacional e descritivo, por meio de dados secundários. Foram incluídas todas as notificações de COVID-19 entre profissionais no Observatório da Enfermagem de 03 abril de 2020 até o dia 26 de maio de 2021. Os dados foram submetidos à análise descritiva. Resultados: 56.114 (100%) casos foram notificados. Dentre as variáveis analisadas, a faixa etária entre 31 a 40 anos foi a mais acometida com 19.761 registros (35,21%), 784 (1,39%) profissionais evoluíram a óbito, com maior predomínio no sexo feminino com 531 (67,72%) notificações. Com relação a letalidade, o sexo masculino somou o maior índice (5,16%). A região Sudeste notificou o maior índice de casos, com destaque para o estado de São Paulo. A faixa etária de 31 a 40 anos, reuniu os maiores índice de afastamento por suspeita de COVID-19 e, em quarentena com 6.074 (36,46%). Conclusão: Os achados permitiram conhecer casos de adoecimento, óbito e letalidade por COVID-19 entre os profissionais de enfermagem, apontando a necessidade urgente de estratégias que minimizem esses riscos em seus ambientes de trabalho.

Resumen: Introducción: El nuevo coronavirus (síndrome respiratorio agudo severo coronavirus-sars-cov-2) se ha propagado rápidamente en todo el mundo causando enfermedad conocida como COVID-19. Esta es una enfermedad respiratoria potencialmente grave, que puede ser una amenaza para la vida de miles de personas, sobre todo profesionales de salud que, debido su exposición ocupacional, son más vulnerables, por lo que integran las estadísticas de caso, la muerte y la letalidad. Objetivo: Describir la situación epidemiológica de las personas profesionales de enfermería en Brasil afectadas por COVID-19. Método: Estudio epidemiológico, observacional y descriptivo, a través de datos secundarios. Se incluyeron todas las notificaciones de COVID-19 de profesionales de salud dentro del Observatorio de Enfermería entre el 3 de abril de 2020 hasta el 26 de mayo de 2021. Los datos se enviaron al análisis descriptivo. Resultados: Se han informado 56 114 (100 %) casos. Entre las variables analizadas, el grupo de edad entre 31 y 40 años fue el más afectado, con 19 761 registros (35.21 %). Además, 784 (1.39 %) profesionales fallecieron, con mayor predominio en mujeres, de quienes hay 531 (67.72 %) notificaciones. Con respecto a la letalidad, los hombres obtuvieron el índice más alto (5.16 %). La región del sudeste notificó los casos más altos, especialmente el estado de São Paulo. El grupo de edad de 31 a 40 años tuvo la tasa de suspensión más alta bajo sospecha de COVID-19, durante la cuarentena fueron 6.074 (36.46%). Conclusión: Los resultados permitieron conocer casos de enfermedad, muerte y letalidad por Covid-19 entre profesionales de enfermería, señalando la necesidad urgente de estrategias que minimicen estos riesgos en sus entornos de trabajo.

Abstract: Introduction: The new coronavirus (Severe Acute Respiratory Syndrome Coronavirus-Sars-COV-2) has quickly spread around the world causing Coronavirus Disease 2019- COVID-19, a potentially severe respiratory disease that is a threat to life. Thousands of people, especially health professionals, increase their vulnerabilities and integrate the statistics of cases, death, and lethality due to occupational exposure. Objective: To describe the epidemiological situation of nursing professionals in Brazil affected by COVID-19. Method: Epidemiological, observational, and descriptive study using secondary data. All COVID-19 notifications were included between professionals at the Nursing Observatory from April 3, 2020, to May 26, 2021. The data were submitted to the descriptive analysis. Results: 56 114 (100 %) cases have been reported. Among the variables analyzed, the age group between 31 and 40 years old was the most affected with a total of 19 761 records (35.21 %), 784 (1.39 %) professionals died, with a greater predominance in female patients: a total of 531 (67.72 %) notifications. Regarding lethality, males added the highest index (5.16 %). The Southeast Region notified the highest cases, especially the state of São Paulo. This age group gathered the highest rate of sick leaves under Covid-19 suspicion and, during the quarantine, they constituted 36.46% (6 074 cases). Conclusion: The findings allowed us to know cases of illness, death, and lethality of COVID-19 among nursing professionals, revealing the urgent need for strategies that minimize these risks in their work environments.

Abstract Objective: to evaluate nursing professionals and patient safety culture during the professional performance in the care of suspected or infected patients with COVID-19. Method: a cross-sectional study carried out with 90 professionals from critical care units of two teaching hospitals. An instrument for sociodemographic characterization and health conditions was used, in addition to the constructs “Nursing professional and patient safety” and the Hospital Survey on Patient Safety Culture. Univariate analyzes were performed between the diagnosis of COVID-19 and the characteristics of Nursing professionals, applying Kendell’s correlation between the constructs. Results: the COVID-19 diagnosis presented a significant statistical difference between nursing professionals that worked for more than six years at the critical care unit (p=0.020) and the items of the construct “Nursing professional and patient safety” regarding the doubts about how to remove the personal protective equipment (p=0.013) and safety flow (p=0,021). The dimensions 2 (p=0.003), 3 (p=0.009), 4 (p=0.013), 6 (p<0.001), and 9 (p=0.024) of the Hospital Survey on Patient Safety Culture were associated with the accomplishment of training. Conclusion: a higher professional nursing experience time was associated with non-infection by COVID-19. The perception of the safety culture of the patient was related to the accomplishment of training.

Resumen Objetivo: evaluar la seguridad de los profesionales de enfermería y la cultura de seguridad del paciente durante su actuación profesional en el cuidado de pacientes sospechosos o con COVID-19. Método: estudio transversal realizado con 90 profesionales de unidades críticas de dos hospitales universitarios. Se utilizó un instrumento de caracterización sociodemográfica y de condiciones de salud, además de los constructos “Seguridad del profesional y del paciente” y Hospital Survey on Patient Safety Culture. Se realizaron análisis univariados entre el diagnóstico de COVID-19 y las características de los profesionales y se aplicó la correlación de Kendell entre los constructos. Resultados: el diagnóstico de COVID-19 mostró diferencia estadísticamente significativa entre los profesionales que actuaron por más de seis años en la unidad (p=0,020) y los ítems del constructo “Seguridad del profesional y del paciente” referentes a dudas sobre cómo retirar el Equipo de Protección Personal (p=0,013) y flujo seguro (p=0,021). Las dimensiones 2 (p=0,003), 3 (p=0,009), 4 (p=0,013), 6 (p<0,001) y 9 (p=0,024) del Hospital Survey on Patient Safety Culture se asociaron a la realización de formación. Conclusión: mayor tiempo de experiencia profesional de enfermería se asoció con la no infección por COVID-19. La percepción de la cultura de seguridad del paciente se relacionó con la realización de entrenamiento.

Resumo Objetivo: avaliar a segurança dos profissionais de enfermagem e a cultura de segurança do paciente durante a atuação profissional no atendimento de pacientes suspeitos ou com COVID-19. Método: estudo transversal realizado com 90 profissionais de unidades críticas de dois hospitais-escola. Foi utilizado um instrumento para caracterização sociodemográfica e condições de saúde, além dos constructos “Segurança do profissional e do paciente” e Hospital Survey on Patient Safety Culture. Foram realizadas análises univariadas entre o diagnóstico de COVID-19 e as características dos profissionais, aplicando-se a correlação de Kendell entre os constructos. Resultados: o diagnóstico de COVID-19 apresentou diferença estatisticamente significativa entre os profissionais que trabalhavam há mais de seis anos na unidade (p=0,020) e os itens do constructo “Segurança do profissional e do paciente” referentes às dúvidas sobre como retirar o equipamento de proteção individual (p=0,013) e fluxo seguro (p=0,021). As dimensões 2 (p=0,003), 3 (p=0,009), 4 (p=0,013), 6 (p<0,001) e 9 (p=0,024) do Hospital Survey on Patient Safety Culture foram associadas à realização de treinamentos. Conclusão: maior tempo de experiência profissional do profissional de enfermagem esteve associado a não infecção por COVID-19. A percepção de cultura de segurança do paciente esteve relacionada à realização de treinamentos.

ABSTRACT Objective: To assess the impact of different vertical positions on lung aeration in patients receiving invasive mechanical ventilation. Methods: An open-label randomized crossover clinical trial was conducted between January and July 2020. Adults receiving invasive mechanical ventilation for > 24 hours and < 7 days with hemodynamic, respiratory and neurological stability were randomly assigned at a 1:1 ratio to the sitting position followed by passive orthostasis condition or the passive orthostasis followed by the sitting position condition. The primary outcome was lung aeration assessed using the lung ultrasound score (score ranges from 0 [better] to 36 [worse]). Results: A total of 186 subjects were screened; of these subjects, 19 were enrolled (57.8% male; mean age, 73.2 years). All participants were assigned to receive at least one verticalization protocol. Passive orthostasis resulted in mean lung ultrasound scores that did not differ significantly from the sitting position (11.0 versus 13.7; mean difference, -2.7; [95%CI -6.1 to 0.71; p = 0.11). Adverse events occurred in three subjects in the passive orthostasis group and in one in the sitting position group (p = 0.99). Conclusion: This analysis did not find significant differences in lung aeration between the sitting and passive orthostasis groups. A randomized crossover clinical trial assessing the impact of vertical positioning on lung aeration in patients receiving invasive mechanical ventilation is feasible. Unfortunately, the study was interrupted due to the need to treat COVID-19 patients. ClinicalTrials.gov registry: NCT04176445

RESUMO Objetivo: Avaliar o impacto de diferentes posicionamentos verticais na aeração pulmonar em pacientes em ventilação mecânica invasiva. Métodos: Trata-se de ensaio clínico aberto, randomizado e transversal, realizado entre janeiro e julho de 2020. Adultos em ventilação mecânica invasiva por mais de 24 horas e menos de 7 dias com estabilidade hemodinâmica, respiratória e neurológica foram distribuídos aleatoriamente em uma proporção de 1:1 à postura sentada seguida da condição de ortostatismo passivo ou o ortostatismo passivo seguido de postura sentada. O desfecho primário foi a aeração pulmonar avaliada pelo lung ultrasound score. O escore varia de zero (melhor) a 36 (pior). Resultados: Foram selecionados 186 indivíduos; destes, 19 foram incluídos (57,8% do sexo masculino; média idade de 73,2 anos). Todos os participantes foram selecionados para receber pelo menos um protocolo de verticalização. O ortostatismo passivo resultou em escores médios de aeração pulmonar por ultrassonografia que não diferiram significativamente da postura sentada (11,0 versus 13,7; diferença média, -2,7; IC95% -6,1 a 0,71; p = 0,11). Ocorreram eventos adversos em três indivíduos no grupo ortostatismo passivo e em um no grupo postura sentada (p = 0,99). Conclusão: Esta análise não encontrou diferenças significativas na aeração pulmonar entre os grupos ortostatismo passivo e postura sentada. É factível conduzir um estudo clínico transversal randomizado para avaliar o impacto do posicionamento vertical na aeração pulmonar em pacientes em ventilação mecânica invasiva. Infelizmente, o estudo foi interrompido devido à necessidade de tratar pacientes com COVID-19. Registro ClinicalTrials.gov: NCT04176445

RESUMO A estabilidade de cor está entre as causas mais frequentes de falhas de restauragoes, que também influenciam suas propriedades superficiais. Objetivo: O objetivo do presente estudo foi investigar a influencia de solugoes de pigmentos em compósitos convencionais e de baixa retragao, bem como alteragoes naspropriedades físicas da superficie dos compósitos. Materiais eMétodo: Amostras de cada compósito (Filtek Z350XT, Point 4, N’Durance e Venus Diamond) foram distribuidas aleatoriamente em grupos submetidos a cada solugao pigmentante (vinho tinto, molho de tomate e café) em ciclos diários de quinze minutos, durante vinte e oito dias. Assim, totalizando 12 grupos (n = 10). Foram realizados testes de cor, rugosidade superficial e dureza. A Análise Estatistica foi realizada usando Análise de variáncia (ANOVA) e o teste de significáncia de Tukey (a = 0.05). Resultados: As alteragoes de cor desencadeadas pelas solugoes investigadas nao mostraram diferenga estatisticamente significativa entre os compósitos Filtek Z350 XT, Venus Diamond e N’Durance. Os valores de dureza registrados para Filtek Z350XT e Venus Diamond diminuiram significativamente após o desafio químico com cada uma das solugoes pigmentantes. Para o fator independente compósito, Venus Diamond registrou a maior rugosidade; foi seguido por Filtek Z350XT, Point 4 e N’Durance. Conclusoes: Os tratamentos das amostras com diferentes solugoes pigmentantes (vinho tinto, molho de tomate e café) aumentaram a manchabilidade dos compósitos convencionais e de baixa retragao e diminuiram sua dureza, embora nao tenham afetado a rugosidade dos compósitos.

ABSTRACT Color stability is among the most frequent causes of restoration failures, and influences surface properties. Aim: The aim of this study was to investigate the influence of pigment solutions on low-shrinkage and conventional composites regarding changes in the physical properties of composite surfaces. Materials and Method: Specimens of four composites (Filtek Z350 XT, Point 4, N’Durance and Venus Diamond) were randomly distributed into three groups to be submitted to each of three pigment solutions (red wine, tomato sauce and coffee) in fifteen-minute daily cycles, for twenty-eight days. There were 12 groups altogether (n = 10). Color, surface roughness and hardness tests were performed. Statistical analysis includedAnalysis of variance (ANOVA) and Tukey’s significance test (a = 0.05). Results: Color changes caused by the solutions did not differ significantly among Filtek Z350 XT, Venus Diamond and N’Durance. Hardness decreased significantly in Filtek Z350 XT and Venus Diamond after chemical challenge with each solution. For the composite independent factor, roughness was highest in Venus Diamond, followed by Filtek Z350 XT, Point 4 and N’Durance. Conclusions: Treatment with different pigment solutions (red wine, tomato sauce or coffee) increased stainability and decreased hardness of both low-shrinkage and conventional composites, while roughness was unaffected.

ABSTRACT Purpose Our objective was to investigate the prevalence of SWA, associated factors, relationship with STIs, and behavioral aspects in men attended at Referral Centers for STIs and acquired immunodeficiency syndrome (AIDS)/CR-STI/AIDS in northeast Brazil. Materials and Methods In this cross-sectional study, a questionnaire with sociodemographic, clinical, sexual and SWA practices information was applied to 400 men attended at two CR-STI/AIDS in Northeast Brazil on the years of 2018 and 2019. Clinical and laboratory diagnoses of STIs were confirmed in medical records. Logistic regression models were performed to identify the independent predictors for SWA. Results The prevalence of SWA over total samples was 15.00%. Of the participants, 239 (59.75%) of the participants were diagnosed with STIs, and of these 37 (15.48%) reported SWA. Most men practiced SWA in adolescence, being the last episode more than 20 years ago, usually with asinine and mules, in vaginal route and without a condom. SWA practitioners have higher percentages of occurrence of some viral STIs. SWA was associated with increasing age, history of residence in a rural area with remained over 12 years, married or widowed/separated, heterosexuals, with less than 7 years of study, Catholics, with hepatitis B, former user of alcoholic beverages and smokers, with a history of STI and intercourse with sex workers. Conclusion SWA practices increase STIs vulnerability. The association between hepatitis B and SWA highlights the importance of educational campaigns and conclusive studies on the topic.

Resumo O presente estudo apresenta uma reflexão sobre a evolução das tecnologias da informação e comunicação e a influência na educação a distância, mais especificamente sobre o recurso da videoaula. Trata-se de um position paper que utiliza a metodologia da pesquisa bibliográfica. Para tanto, inicia com uma breve análise sobre o conceito de tecnologia e a relação direta com a evolução dessa modalidade de ensino, que foi categorizada historicamente em cinco gerações. Propõe a existência atual de uma sexta geração da educação a distância com o advento do mobile learning e o ensino remoto emergencial, evidenciado no ano de 2020 com as consequências da pandemia de COVID-19 na educação. Ao final apresenta as características, diferenças e potencialidades no uso da videoaula na educação a distância e no ensino remoto e o reflexo no planejamento do trabalho docente.

Abstract This study presents a reflection on the evolution of information and communication technologies and their influence on distance education, more specifically on the resource of video classes. It is a position paper that uses the methodology of bibliographic research.Therefore, it begins with a brief analysis of the concept of technology and its direct relationship with the evolution of this teaching modality, which has been historically categorized into five generations. It proposes the current existence of a sixth generation of distance education with the advent of mobile learning and emergency remote teaching, evidenced in 2020 with the consequences of the COVID-19 pandemic in education. At the end, it presents the characteristics, differences and potentialities in the use of video classes in distance education and remote teaching and the reflection on the teaching workload.

ABSTRACT The correct nutrition of orchards from fertilizer management directly influences fruit yield. Therefore, the objective was to evaluate the nutritional status of orchards of the ‘Montenegrina’ mandarin (Citrus deliciosa Tenore) grafted on Poncirus trifoliata Raf. in southern Brazil. The study included analyzes of soil and leaf tissue from 58 commercial orchards. More than 60% of the orchards were diagnosed with K and Mg insufficiency and more than 30% had an excess of N. There was an insufficiency in Mn and Zn of 60 and 96%, respectively, despite the levels of these micronutrients in the soil being high in both depths studied. In addition, no significant correlations were observed between the contents of a given nutrient in the soil and in the leaves, except for the Ca/Mg ratio. Insufficiency was observed in the leaf contents of K, Mg, Mn and Zn and excesses of N and Cu in the orchards. The use of phosphate and potassium fertilizers requires adjustments due to the excessive content of these nutrients in the soil. Pre-planting acidity correction and soil acidity management in ‘Montenegrina’ mandarin orchards already implanted needs to be optimized.

RESUMO Objetivo: Descrever a prevalência de duração do sono, latência, insônia terminal, qualidade subjetiva do sono e sonolência diurna excessiva entre participantes de coortes de nascimentos realizadas em três cidades brasileiras, bem como avaliar as diferenças nas taxas de prevalência das coortes de acordo com características sociodemográficas. Métodos: Análises transversais envolvendo participantes de quatro coortes de nascimento realizadas em Ribeirão Preto (RP78 e RP94), Pelotas (PEL93) e São Luís (SL97). A duração, a latência, a insônia terminal e a qualidade subjetiva do sono foram obtidas por meio do Índice de Qualidade do Sono de Pittsburgh; e a sonolência diurna excessiva foi avaliada pela Escala de Sonolência de Epworth. As diferenças na prevalência dos desfechos foram analisadas em cada coorte segundo características sociodemográficas estratificadas por sexo. Resultados: A duração insuficiente do sono foi o desfecho mais comum nas quatro coortes, com maior frequência entre os homens. Latência longa foi mais frequentemente relatada por mulheres adultas jovens nas coortes RP94 e PEL93, e insônia por mulheres das quatro coortes, quando comparadas a homens da mesma idade. As mulheres geralmente sofriam mais com sonolência diurna excessiva e avaliavam a qualidade do sono de forma mais negativa do que os homens. Além do sexo, ser estudante e trabalhar estiveram associados ao maior número de desfechos em ambos os sexos. Conclusão: Os distúrbios do sono são mais prevalentes em mulheres, reforçando a necessidade de maior investimento na saúde do sono no Brasil, sem desconsiderar gênero e determinantes socioeconômicos.

ABSTRACT Objective: To describe the prevalence of insufficient sleep duration, long sleep latency, terminal or maintenance insomnia, subjective sleep quality, and excessive daytime sleepiness among participants of birth cohorts conducted in three Brazilian cities, and to evaluate differences in prevalence rates within cohorts according to sociodemographic characteristics. Methods: Cross-sectional analyses involving adolescents and adults participating in four birth cohorts conducted in Ribeirão Preto (RP78 and RP94), Pelotas (PEL93) and São Luís (SL97/98). Sleep duration, latency, terminal or maintenance insomnia, and subjective sleep quality were obtained through the Pittsburgh Sleep Quality Index; and excessive daytime sleepiness was assessed using the Epworth Sleepiness Scale. Differences in the prevalence of the outcomes were analyzed in each cohort according to sociodemographic characteristics (skin color, marital status, socioeconomic status, study and working at the time of the interview) stratified by sex. Results: Insufficient sleep duration was the most common outcome at the four cohorts, with higher frequency among men. Long latency was more frequently reported by young adult women in RP94 and PEL93 cohorts, and insomnia by women of the four cohorts, when compared to men of the same age. Women generally suffered more from excessive daytime sleepiness and evaluated the quality of their sleep more negatively than men. In addition to sex, being a student and working were associated with the largest number of outcomes in both sexes. Conclusion: Sleep disorders are more prevalent in women, reinforcing the need for greater investment in sleep health in Brazil, without disregarding gender and socioeconomic determinants.

Abstract Cunila galioides Benth. is an aromatic and medicinal plant widely used in the traditional medicine of South Brazil. The essential oil of one of its chemotypes has high citral contents, an oxygenated monoterpene used in perfumery, cosmetics, and food industries. The seeds of C. galioides have low germination percentages and there are few studies regarding its vegetative propagation. Thus, this study aimed to evaluate distinct indole-3-butyric acid concentrations (0 - control, 250, 500, and 1,000 mg∙L-1) on the rooting of herbaceous cuttings of C. galioides and different methods (gibberellic acid, potassium nitrate, and stratification) to overcome a possible dormancy in the seeds. In vegetative propagation, the use of indole-3-butyric acid 250 mg∙L-1 only increased root score relative to the control, and higher IBA concentrations had no effective response on the cuttings, not being necessary to use IBA in C. galioides cuttings. The most effective treatments regarding seed germination were gibberellic acid and potassium nitrate, with germination percentages of 57.8 % and 54.5 %, respectively; stratification was not effective in increasing the germination percentage of the seeds relative to the control.

ABSTRACT Online hemodiafiltration (HDF) is a rapidly growing dialysis modality worldwide. In Brazil, the number of patients with private health insurance undergoing HDF has exceeded the number of patients on peritoneal dialysis. The achievement of a high convection volume was associated with better clinical imprand patient – reported outcomes confirming the benefits of HDF. The HDFit trial provided relevant practical information on the implementation of online HDF in dialysis centers in Brazil. This article aims to disseminate technical information to improve the quality and safety of this new dialysis modality.

RESUMO A hemodiafiltração (HDF) on-line é uma modalidade dialítica em rápido crescimento no mundo. No Brasil, o número de pacientes com planos de saúde privados tratados por HDF já ultrapassa aquele de pacientes em diálise peritoneal. O alcance de um alto volume convectivo associado à redução de desfechos clínicos e do risco de morte confirmam os benefícios da HDF. Dados nacionais do estudo HDFit forneceram informações práticas relevantes sobre a implementação da HDF on-line em clínicas de diálise no Brasil. O objetivo desta publicação é a disseminação de informações técnicas que possam auxiliar na utilização, com qualidade e segurança, dessa nova modalidade dialítica.